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About Exeter and the South West
College of Engineering, Mathematics and Physical Sciences
This post is available immediately for a fixed term period of 33 months.
The College wishes to recruit an Associate Research Fellow for a collaborative project between the labs of Dr. Orkun S. Soyer and Prof. Richard Titball. The successful applicant will contribute towards research related to the project entitled 'Deciphering The Molecular Basis of Environmental Persistence in Campylobacter Using a Systems Approach'. This project is funded by BBSRC through the BBSRC/FSA/DEFRA joint Campylobacter research with industry call.
Campylobacter jejuni (Cj) remains a leading cause of food borne infection in the UK with most cases arising from the ingestion of contaminated poultry. Cj is able to survive unfavourable conditions such as antibiotic treatment by forming metabolically inactive cells (persister cells). These cells serve as an environmental reservoir and a source of infection, thus, a full understanding and control of food borne infection mediated by Cj requires an understanding of the formation and regulation of the persister cell phenotype. We will undertake an integrated analysis of persister cell formation and its molecular basis in Cj, that will ultimately enable us to design novel approaches towards reducing Cj levels in the food chain.
The successful candidate will undertake theoretical and computational work under this project. In particular, s/he is expected to build theoretical and evolutionary systems biology models of molecular systems underlying persister formation and stochastic switching. This modelling work will be done in conjunction with the experimental characterisation of Cj persister cells and will feed from and provide direction to these experiments.
The successful applicant will possess a relevant PhD and be able to demonstrate sufficient knowledge in theoretical modelling of cellular systems, analysis of data coming out of such models, and integration and analysis of experimental data. S/he should be sufficient in common system analysis and modelling tools (e.g. MATLAB), able to command at least one computer language (e.g. JAVA), and experienced in data analysis and coding. In addition, the successful candidate should have a good knowledge of cellular biology and be able to communicate and collaborate with experimental scientists and distil research findings in a comprehensive way.
For further information please contact Dr. Orkun S. Soyer O.S.Soyer@exter.ac.uk
To view the Job Description and Person Specification document please click here.
The University of Exeter is an equal opportunity employer which is 'Positive About Disabled People': if you have a disability, you should mention this in your application. Whilst all applicants will be judged on merit alone, we particularly welcome applications from groups currently underrepresented in the workforce.
HOW TO APPLY FOR THIS POSITION:
Please send your CV, covering letter (detailing your motivation) and the details of three referees to Orkun S. Soyer at O.S.Soyer@exeter.ac.uk, quoting the job reference P42372 in any correspondence.
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